Search results for " Idiopathic"

showing 10 items of 94 documents

Histamin in der Interstitialfl�ssigkeit der befallenen und klinisch nicht befallenen Haut bei chronisch rezidivierender Urticaria

1979

Bei 8 Patienten mit idiopathischer chronisch rezidivierender Urticaria wurden in der Periumbilicalregion Saugblasen gleichzeitig auf frischen urticariellen Herden und der unveranderten Haut daneben produziert und Histamin in der Blasenflussigkeit bestimmt. Hierzu wurde die von Siraganian entwickelte Methode der Autoanalyzer-Technik in modifizierter Form verwendet. Die Histaminspiegel lagen bei diesen Patienten in unveranderter Haut in derselben Grosenordnung wie bei 10 Normalpersonen, wahrend alle 8 Urticaria-Patienten hohere Histamin-Werte in den Urticae verglichen mit der nicht befallenen Haut aufwiesen; bei 4 der Patienten waren diese Unterschiede jedoch nur gering ausgepragt.

Gynecologychemistry.chemical_compoundmedicine.medical_specialtychemistrybusiness.industryInterstitial fluidMedicineIn patientDermatologyGeneral MedicineChronic idiopathic urticariabusinessHistamineArchives of Dermatological Research
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Anakinra drug retention rate and predictive factors of long-term response in systemic juvenile idiopathic arthritis and adult onset still disease

2019

Background and Objective: Only a few studies have reported long-term efficacy of interleukin (IL)-1 inhibition in systemic juvenile idiopathic arthritis (sJIA) and adult-onset Still disease (AOSD). Herein we report on the effectiveness of anakinra (ANA), expressed in terms of drug retention rate (DRR), and evaluate the predictive factors of drug survival in a cohort of patients with sJIA and AOSD. Patients and Methods: This is a multicenter study reviewing retrospectively the medical records from 61 patients with sJIA and 76 with AOSD, all treated with ANA in 25 Italian tertiary referral centers. Results: The cumulative retention rate of ANA at 12-, 24-, 48-, and 60-month of follow-up was 7…

0301 basic medicineAdult onset Still diseasemedicine.medical_specialtyArthritisStill DiseaseAdult onset Still disease; Anakinra; Drug retention rate; Innovative biotechnologies; Interleukin 1-beta; Personalized medicine; Systemic juvenile idiopathic arthritis03 medical and health sciences0302 clinical medicineSettore MED/38 - Pediatria Generale E Specialisticaanakinra interleukin 1-beta innovative biotechnologies drug retention rate systemic juvenile idiopathic arthritis adult onset Still disease personalized medicineSystemic juvenile idiopathic arthritisInternal medicinemedicinePharmacology (medical)Adverse effectOriginal ResearchPharmacologyAnakinrabusiness.industryHazard ratiolcsh:RM1-950Innovative biotechnologiesmedicine.diseaseDrug retention ratePersonalized medicineConfidence intervalAdult onset Still disease Anakinra Drug retention rate Innovative biotechnologies Interleukin 1-beta Personalized medicine Systemic juvenile idiopathic arthritisDiscontinuation030104 developmental biologylcsh:Therapeutics. PharmacologyAnakinraInnovative biotechnologie030220 oncology & carcinogenesisCohortInterleukin 1-betabusinessmedicine.drug
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Botox® for idiopathic overactive bladder: efficacy, duration and safety. Effectiveness of subsequent injection

2012

Purpose To test the efficacy, duration and safety of 100 U of botulinum toxin type A (BoNT/A) in women affected by idiopathic detrusor overactivity (IDO) and the effectiveness of subsequent injections. Methods In this double centre, prospective study con- ducted from March 2008 to March 2010, we selected women affected by IDO who failed to respond to various antimuscarinic agents, reported intolerable anticholinergic side-effects or contraindication to their use, also without any response to tibial stimulation. Medical history, physi- cal examination, standard urodynamic examination, uri- nalysis, urine culture, a 4-day voiding diary and a quality of life questionnaire were requested for al…

AdultReoperationurge incontinencemedicine.medical_specialtyUrge incontinenceidiopathic overactive bladderUrologyBotox Idiopathic overactive bladder Urge incontinence Idiopathic detrusor overactivity Botulinum toxin type AInjections IntramuscularBotox idiopathic overactive bladder urge incontinence idiopathic detrusor overactivity botulinum toxin type A.medicineHumansProspective StudiesBotulinum Toxins Type ADuration (project management)Safety effectivenessAgedBotoxUrinary Bladder Overactivebusiness.industryObstetrics and GynecologyCystoscopyGeneral MedicineMiddle Agedmedicine.diseaseSettore MED/40 - Ginecologia E Ostetriciabotulinum toxin type Aidiopathic detrusor overactivityTreatment OutcomeOveractive bladderFemalemedicine.symptombusinessBotulinum toxin typeArchives of Gynecology and Obstetrics
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Relationship Between Human Leucocyte Antigen Class I and Class II and Chronic Idiopathic Urticaria Associated With Aspirin and/or NSAIDs Hypersensiti…

2006

Background. HLA genes play a role in the predisposition of several diseases. The aim was to analyze the prevalence of HLA class I phenotypes and HLA-DRB1*genotype in patients with CIU associated with ASA and NSAIDs hypersensitivity (AICU).Methods. 69 patients with AICU, and 200 healthy subjects.Results. Subjects with HLA-B44 and HLA-Cw5 antigens were more represented in patients with AICU than in control group. Subjects with HLA-A11, HLA-B13, HLACw4, and HLA-Cw7 antigen were more represented in control group than in patients with AICU. Multiple logistic regression demonstrated an association of HLA-Cw4 and HLA-Cw7 with a lower risk of AICU, whereas carriers of HLA-B44 phenotype had a higher…

AdultMaleSettore MED/09 - Medicina InternaChronic Idiopathic UrticariaGenotypeUrticariahuman leucocyte antigen class IImmunologyGenes MHC Class IIAnti-Inflammatory AgentsHuman leukocyte antigenLower riskDrug HypersensitivityResearch CommunicationAntigenGene FrequencyRisk FactorsGenotypelcsh:PathologyMedicineHumansAlleleAllele frequencyAllelesAspirinAspirinbusiness.industryAnti-Inflammatory Agents Non-SteroidalHistocompatibility Antigens Class ICase-control studyCell BiologyHLA-DR AntigensMiddle AgedNSAIDhuman leucocyte antigen class I; human leucocyte antigen class II; chronic idiopathic urticaria; aspirin; NSAIDs; hypersensitivityhuman leucocyte antigen class IIMHC Class IIPhenotypeGenesCase-Control StudiesImmunologyFemalehypersensitivityNon-Steroidalbusinesslcsh:RB1-214medicine.drugHLA-DRB1 ChainsMediators of Inflammation
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La Valle dei Templi in epoca medioevale. Caratterizzazione antropologica e paleopatologica delle sepolture antistanti in Tempio della Concordia

2021

Riassunto ― Il lavoro presenta i risultati delle analisi bio-archeologiche effettuate su resti scheletrici umani rinvenuti in quattordici sepolture di epoca medioevale rinvenute nel Parco Archeologico della Valle dei Templi di Agrigento (Sicilia). L’obiettivo è stato l’acquisizione delle informazioni necessarie per la ricostruzione del profilo biologico di ciascun individuo, al fine di determinarne il sesso, la stima dell’età biologica alla morte, la stima della statura e la valutazione delle patologie e degli indicatori di stress occupazionale mediante le correnti metodologie e tecniche diagnostiche di tipo antropologico. Sebbene il cattivo stato di conservazione di alcuni individui non ne…

Summary ― The work presents the results of the bio-archaeological analyzes carried out on human skeletal remains found in fourteen burials of Medieval chronology at the Archaeological Park of Valle dei Templi in Agrigentum (Sicily). The aim of the work was the acquisition of the information necessary for the reconstruction of the biological profile of each individual throught the determination of sex the estimate of the biological age at death the estimate of height and the evaluation of pathologies and markers of occupational stress through current anthropological diagnostic methodologies and techniques. Althought the poor state of conservation of some individuals has not allowed their whole anthropological characterization the investigations have highlighted the heterogeneity relating to the age groups and have allowed us to ascertain the presence of pathological alterations in subjects of mature age sometimes of unknown etiology such as DISH (Diffuse Idiopathic Hyperostosis). The sample size is not representative of the entire population but subsequent insights will provide a better understanding of the population dynamics of Medieval Agrigentum.Settore BIO/08 - Antropologia
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The EAACI/GA2LEN/EDF/WAO Guideline for the definition, classification, diagnosis, and management of urticaria: the 2013 revision and update

2014

This guideline is the result of a systematic literature review using the 'Grading of Recommendations Assessment, Development and Evaluation' (GRADE) methodology and a structured consensus conference held on 28 and 29 November 2012, in Berlin. It is a joint initiative of the Dermatology Section of the European Academy of Allergy and Clinical Immunology (EAACI), the EU-funded network of excellence, the Global Allergy and Asthma European Network (GA(2)LEN), the European Dermatology Forum (EDF), and the World Allergy Organization (WAO) with the participation of delegates of 21 national and international societies. Urticaria is a frequent, mast cell-driven disease, presenting with wheals, angioe…

Allergymedicine.medical_specialtyhivesImmunologylcsh:Medicine610 Medicine & healthDermatologyDiseaseurticariaimmune system diseaseslcsh:DermatologyHumansImmunology and AllergyMedicinemedia_common.cataloged_instanceEuropean unionskin and connective tissue diseaseswhealAsthmamedia_common2403 ImmunologyAcute urticariaAngioedemabusiness.industryangioedemalcsh:RConsensus conferenceangioedema; consensus; hives; urticaria; wheal; Humans; Urticaria10177 Dermatology ClinicGuidelinelcsh:RL1-803angioedema consensus hives urticaria wheal CHRONIC IDIOPATHIC URTICARIA QUALITY-OF-LIFE SERUM SKIN-TEST DELAYED PRESSURE URTICARIA DOSE INTRAVENOUS IMMUNOGLOBULIN ANTIIMMUNOGLOBULIN-E THERAPY RESISTANT CHRONIC URTICARIA RANDOMIZED CONTROLLED-TRIAL ULTRAVIOLET-B PHOTOTHERAPY WORLD-HEALTH-ORGANIZATIONmedicine.diseaseDermatologySystematic reviewconsensusFamily medicine2723 Immunology and Allergymedicine.symptombusinessAllergy
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Epidemiology, diagnosis and management of hirsutism: a consensus statement by the Androgen Excess and Polycystic Ovary Syndrome Society.

2012

Background Hirsutism, defined by the presence of excessive terminal hair in androgen-sensitive areas of the female body, is one of the most common disorders in women during reproductive age. Methods We conducted a systematic review and critical assessment of the available evidence pertaining to the epidemiology, pathophysiology, diagnosis and management of hirsutism. Results The prevalence of hirsutism is ~10% in most populations, with the important exception of Far-East Asian women who present hirsutism less frequently. Although usually caused by relatively benign functional conditions, with the polycystic ovary syndrome leading the list of the most frequent etiologies, hirsutism may be th…

hirsutism; androgen excess; guidelinesmedicine.medical_specialtyPediatricsHirsutismMEDLINETerminal hairAndrogen ExcessSettore MED/13 - EndocrinologiaIntervention (counseling)EpidemiologyMedicineHumansguidelineshirsutismSocieties MedicalHirsutism PCOS Hyperandrogenism Adrenal hyperplasia idiopathic hirsutismGynecologybusiness.industryObstetrics and Gynecologymedicine.diseaseSettore MED/40 - Ginecologia E OstetriciaPolycystic ovaryReproductive Medicinehirsutism androgen excess terminal hair polycystic ovary syndrome guidelinesEtiologyAndrogensFemaleandrogen excessbusinessHair FolliclePolycystic Ovary SyndromeHuman reproduction update
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Musculoskeletal manifestations of childhood cancer and differential diagnosis with juvenile idiopathic arthritis (ONCOREUM): a multicentre, cross-sec…

2021

Summary Background Presenting symptoms of childhood cancers might mimic those of rheumatic diseases. However, the evidence available to guide differential diagnosis remains scarce. Preventing wrong or delayed diagnosis is therefore important to avoid incorrect administration of glucocorticoid or immunosuppressive therapy and worsening of prognosis. As such, we aimed to assess the prevalence and characteristics of presenting musculoskeletal manifestations in patients at cancer onset and to identify the factors that differentiate childhood malignancies with arthropathy from juvenile idiopathic arthritis. Methods We did a multicentre, cross-sectional study at 25 paediatric haemato-oncology cen…

medicine.medical_specialtybusiness.industryImmunologyArthritisCancerOdds ratioMusculoskeletal manifestationJuvenile idiopathic arthritismedicine.diseaseHistiocytosisRheumatologySettore MED/38 - PEDIATRIA GENERALE E SPECIALISTICAPrednisoneInternal medicineJoint painArthropathyMusculoskeletal manifestations childhood cancer juvenile idiopathic arthritismedicinechildhood cancerImmunology and AllergyDifferential diagnosismedicine.symptombusinessmedicine.drug
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Controversies and challenges in the management of chronic urticaria

2016

This supplement reports proceedings of the second international Global Urticaria Forum, which was held in Berlin, Germany in November 2015. Despite the clear international guideline, there remain a number of controversies and challenges in the management of patients with chronic urticaria (CU). As a result of major advancements in urticaria over the past 4 years, the current EAACI/GA(2) LEN/EDF/WAO urticaria guideline treatment algorithm requires updating. Case studies from patients with chronic spontaneous urticaria (CSU) [also called chronic idiopathic urticaria (CIU)], chronic inducible urticaria (CIndU) or diseases and syndromes related to CU are useful in describing and exploring chall…

AdultMalemedicine.medical_specialtyPathologyUrticariaAlternative medicineDermatologyUnmet needs030207 dermatology & venereal diseases03 medical and health sciences0302 clinical medicineimmune system diseasesparasitic diseasesmedicineHumansAngioedemaDisease management (health)ChildIntensive care medicineskin and connective tissue diseasesChronic urticariaAgedbusiness.industryGuidelineMiddle AgedPedigreeCold TemperatureInfectious Diseases030228 respiratory systemChronic DiseaseHistamine H1 AntagonistsSunlightFemaleChronic idiopathic urticariabusiness
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DEVELOPMENT AND INITIAL VALIDATION OF THE SYSTEMIC JADAS, A NEW COMPOSITE DISEASE ACTIVITY SCORE FOR SYSTEMIC JUVENILE IDIOPATHIC ARTHRITIS

2019

Background: Juvenile Arthritis Disease Activity Score (JADAS) has gained increasing popularity for the measurement of the level of disease activity in patients with juvenile idiopathic arthritis (JIA). However, so far the JADAS has been validated only in children with the non-systemic categories of JIA. Objectives: To develop and validate the systemic JADAS (sJADAS), a new version of the JADAS specific to systemic JIA (sJIA). Methods: The sJADAS is made up by adding a fifth item, named Systemic Manifestation Score (SMS), to the four items included in the original tool (physician global assessment of disease activity, parent/patient global assessment of well-being, active joint count and ery…

Settore MED/38 - Pediatria Generale E SpecialisticaJADAS Juvenile Idiopathic Arthritis disease activity
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